Paxil

Taking Shape: film-coated tablet 20 mg, 30 mg
The content of active substance - Paroxetine

Table 1. shell. contains 20 mg of paroxetine.
Alternative medicine Paroxetine

Mode of action Paxil selectively prolongs the action of serotonin. Relief from depression, panic, forced thoughts and actions. This medicine does not affect the psychomotor activity does not increase blood pressure, no effect on heart function.


Antidepressant. Strong and selective serotonin reuptake inhibitor (5-hydroxytryptamine, 5-HT). Paroxetine has little affinity for muscarinic receptors, has weak anticholinergic properties, low affinity for the receptors: adrenergic a1, a2 and b, dopamine (D2), serotonin 5-HT1, 5-HT2 and histamine (H1).
Does not inhibit the CNS, no hypotensive properties, and does not impair psychomotor function. Well absorbed from the gastrointestinal tract after oral administration and undergoes first-pass; conc. Taking the steady state is determined after approximately 7-14 days of starting treatment, approximately 95% of the drug binds to proteins, 64% of the dose is excreted in the urine as metabolites, the remaining 36% in the faeces, probably via the bile.
Application of moderate Depression. Anxiety. Geriatric Depression. Agoraphobia. Coercive acts and thoughts.
Warning injection should not be used in patients with hepatic or renal impairment. The drug should be used with caution in patients with epilepsy. Paxil can't be given to children.
The expected effect of treatment may change if paroxetine used in combination with other medicines. It should therefore consult your doctor if you wish to use other drugs, including preparation. Preparation should be avoided, including dextrometorfan, quinidine, moclobemide and selegiline. Paroxetine inhibits the activity of the enzyme P-450, which aggravates the metabolism of other drugs administered concomitantly with Paxil. Drug therapy in conjunction with MAO inhibitors may cause serotonergical syndrome. You have to keep at least 14 days interval after treatment with MAO inhibitors before taking the treatment Paxil. Patients with suicidal intentions under the influence of drug may deteriorate - the risk of suicide may get worse, especially in the first period of treatment. Symptoms of psychotic patients mono depressed can go a manic phase. Completion of treatment should be gradual, i.e. the drug should be withdrawn gradually reducing the dosage as recommended by your doctor.


Increased risk of suicidal behavior. Caution in patients with a history of mania in patients with severe renal or hepatic impairment, in patients with epilepsy, with seizure disorders in patients with glaucoma narrow-angle glaucoma or a history of glaucoma and in patients with cardiovascular disorders, bleeding or a history of states that predispose to bleeding, and patients at risk for hyponatremia.
Side effects> 1 / 100
- Dizziness.
- Excessive sweating.
- Increase or decrease in body weight.
- Syncope.
- Accelerated heart rate.
- The decline in blood pressure when changing the vertical posture.
- Insomnia.
- The over-excitement.
- Tremor of muscles.
- Anxiety.
- The deterioration of concentration, sexual dysfunction.
- Tingling in the extremities.
- Nausea, vomiting, diarrhea.
- Flatulence.
- Dry mouth and therefore need the exact health of teeth after every meal.
- Disturbances in urination.
- Seeing through the fog.

1 / 1000
- Swelling of the face and extremities.
- Excessive appetite.
- Emotional disturbances, especially in women.
- Difficulty in swallowing.
- Rash and itching.
- Extension of the pupils.
- Weakness in the muscles.
- Tinnitus.

<1 / 1000
- The decrease in platelet count.
- Galactorrhea.
- The internal haemorrhages.
- Changes in liver function.
- Extrapyramidal disorder manifested beyond the twitches of the face and limb movements.
- Acute attacks of glaucoma.


Abnormal bleeding, usually affecting the skin and mucous membranes (mostly ecchymosis), thrombocytopenia. Allergic reactions (including urticaria and angioedema). Team inappropriate secretion of antidiuretic hormone (ADH). Decreased appetite, hyponatremia. Somnolence, insomnia, confusion, hallucination, mania, agitation, anxiety, depersonalisation, panic attacks, akathisia. Dizziness, tremor, extrapyramidal symptoms, seizures, serotonin syndrome (symptoms: agitation, confusion, sweating, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor). Blurred vision, acute glaucoma. Sinus tachycardia, bradycardia. Transient decrease or increase blood pressure. Yawn. Nausea, constipation, diarrhea, dry mouth. Elevated liver enzymes, liver dysfunction (hepatitis, associated with jaundice and liver failure). Sweating, rash, itching, sensitivity to light. Urinary retention. Sexual dysfunction, hyperprolactinaemia / galactorrhoea, priapism. Joint pain, muscle pain. Weakness, weight gain, peripheral edema.
Symptoms after discontinuation of treatment: dizziness, sensory disturbances, sleep disturbances, anxiety, headache, agitation, nausea, tremor, confusional state, sweating, emotional instability, visual disturbances, palpitations, diarrhea, irritability and visual disturbances.
Adult dosage of 20 mg once daily at breakfast. The dose may be a need to expand to 50 mg. Patients who are over 65 years of age shall be a maximum of 20 mg / day.


Depressive episode: 20 mg / day, max. 50 mg / day, duration of treatment: at least 6 months, improving the patient's condition begins after 1-2 weeks Social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder: The recommended daily dose of 20 mg / day, increased by 10 mg to max. dose of 50 mg / day, long-term therapy should be regularly evaluated. Obsessive-compulsive disorder: the recommended daily dose of 40 mg, the initial 20 mg / day, increased gradually to 10 mg, the recommended dose, max. 60 mg / day, duration of treatment: a few months old. Anxiety disorders with anxiety attacks: the recommended daily dose of 40 mg, the initial 10 mg / day, increased gradually to 10 mg, max. 60 mg / day, duration of treatment: a few months old. Avoid sudden discontinuation of treatment to reduce the daily dose of 10 mg / week. Elderly: max. dose <40 mg / day. Renal failure or liver disease: the lower dose range.